Pain relief & fever · NSAID (Non-steroidal anti-inflammatory)
Naproxen
Naproxen is a longer-acting NSAID used for pain, inflammation, and fever. Typical effects last around 8 to 12 hours.
OTCPregnancy warningKidney warningLiver warningAlcohol interactionNot for young childrenSenior precautionOverview & typical uses
Naproxen is a longer-acting NSAID used for pain, inflammation, and fever. Typical effects last around 8 to 12 hours.
Primary uses
- Muscle and joint pain
- Menstrual cramps
- Mild to moderate headache
- Fever comfort
How it works
Blocks cyclo-oxygenase enzymes, reducing prostaglandins that drive pain, fever, and inflammation.
Available forms & strengths
- Tablet — 220 mg, 250 mg, 500 mg (Oral)
General precautions & contraindications
Do not use if
- Active stomach or duodenal ulcer
- Severe heart, kidney, or liver disease
- Third trimester of pregnancy
Pregnancy
Not recommended in pregnancy. Best avoided, particularly after 20 weeks. Paracetamol is usually preferred.
Breastfeeding
Use with caution — discuss with clinician. Small amounts pass into breast milk; short-term occasional use is usually acceptable.
Kidney considerations
- Avoid in significant kidney disease.
- Stay well hydrated during use.
Liver considerations
- Discuss with a clinician if you have liver disease.
Paediatric use
Generally reserved for older children under clinical supervision.
Older adults
Higher risk of GI, kidney, and cardiovascular side effects — prefer paracetamol first.
Common side effects
- Indigestion or heartburn
- Nausea
- Dizziness or drowsiness
Serious warnings — seek help if these appear
- Stomach ulcers or gastrointestinal bleeding
- Kidney injury
- Serious allergic reactions
- Increased risk of heart attack or stroke with prolonged high use
Drug interactions
Do not combine — additive stomach and kidney risk.
Increased bleeding risk.
Naproxen can raise blood levels of these medicines.
Reduced blood pressure control and kidney strain.
Food & alcohol precautions
Increases risk of stomach irritation and bleeding.
Taking with food reduces stomach upset.
Alcohol
- Alcohol raises the risk of stomach irritation and bleeding.
Storage, missed dose & overdose
Storage
Store below 25 °C in a dry place, out of reach of children.
If a dose is missed
Take a missed dose as soon as remembered unless the next scheduled time is near — do not double up.
Overdose
Overdose can cause drowsiness, stomach pain, kidney injury. Seek urgent medical help.
What to monitor
- Watch for black stools, unusual bruising, ankle swelling.
Frequently asked questions
Around 8 to 12 hours per dose — typically taken twice daily.
Medical references
- British National Formulary — Naproxen — BNF (NICE)
- FDA drug information — NSAIDs — U.S. Food & Drug Administration
Content last reviewed: 2025-01-01
Medical disclaimer
This information is for educational purposes only and should not replace professional medical advice. Please consult a licensed pharmacist or clinician for advice tailored to your personal circumstances.